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High-rate pulmonary involvement in autoimmune pancreatitis

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Autoimmune pancreatitis (AIP) has extrapancreatic complications such as Sjögren's syndrome, retroperitoneal fibrosis and sclerosing cholangitis. We studied 30 patients with AIP. Of these, we identified pulmonary involvement in four patients during follow up. Among them, two patients had respiratory failure. They showed good response to steroid therapy, but a higher dose of prednisolone was necessary to maintain remission than that required in biliary involvement. Elevation of immunoglobulin G4 and Krebs von den Lungen-6 levels were characteristic of pulmonary involvement. They may be useful for early detection of pulmonary complication.
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Keywords: IgG4; KL-6; autoimmune pancreatitis; interstitial pneumonia

Document Type: Research Article

Affiliations: Department of Gastroenterology, University of Tokyo, Tokyo, Japan

Publication date: 2006-01-01

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