Skip to main content

Symptomatic hypocalcaemia and renal impairment associated with bisphosphonate treatment in patients with multiple myeloma

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract

We report three cases of severe hypocalcaemia associated with i.v. bisphosphonate treatment in patients with multiple myeloma. All patients had symptomatic hypocalcaemia, including a tonic-clonic seizure and tachyarrhythmia in one case. Two cases were associated with the development of acute renal failure, whereas the third patient had pre-existing renal impairment. We recommend that bisphosphonates be used with caution in patients with myeloma and renal impairment, that vitamin D deficiency be corrected prior to treatment (to reduce the risk of hypocalcaemia) and that serum calcium and renal function be monitored during treatment. (Intern Med J 2005; 35: 726–728)
No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: bisphosphonate; hypocalcaemia; multiple myeloma; pamidronate; zoledronate

Document Type: Research Article

Affiliations: 1: Department of Endocrinology and Diabetes, Royal Perth Hospital 2: Endocrinology and Diabetes 3: Haematology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia

Publication date: 2005-12-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more