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Histiocytosis and bone: experience from one major Sydney teaching hospital

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Langerhans cell histiocytosis (LCH) has diverse presentations which can bring it before all physicians regardless of specialty. A retrospective audit was undertaken at Westmead Hospital, Sydney, Australia, to ascertain the incidence, epidemiology and clinical features of patients with LCH over a 10-year period (1994–2004). A total of 12 patients was identified (six male, six female). Eleven patients had involvement of the skeletal system, three of the patients had pulmonary LCH and only one patient presented with soft tissue involvement (nose and antrum). Three patients had diabetes insipidus. Our results are consistent with that noted in the published literature and confirm the low incidence, diverse nature of presentation and the differing treatment strategies available for this rare and yet interesting condition. (Intern Med J 2005; 35: 622–625)

Keywords: Hand–Schuller–Christian disease; Langerhans cell; Letterer–Siwe disease; bone; eosinophilic granuloma; histiocytosis

Document Type: Research Article


Affiliations: 1: Western Clinical School, University of Sydney 2: Rheumatology Department, Westmead Hospital, Sydney 3: Nepean Cancer Care Centre, Nepean Hospital, Sydney, New South Wales, Australia

Publication date: 2005-10-01

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