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Direct comparison of 18F-fluorodeoxyglucose coincidence gamma camera tomography with gallium scanning for the staging of lymphoma

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Abstract Background: 

The present study compared the performance of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) using a coincidence dual-head gamma camera (FDG Co-PET) with 67gallium scinti graphy (GS) in pretreatment staging of lymphoma. Methods: 

A total of 46 patients underwent FDG Co‐PET, computed tomography (CT) scanning and GS for pretreatment staging of lymphoma (40 newly diagnosed and recurrence) between November 1997 and December 1999. Results: 

Histological subgroups comprised low grade (8 patients), intermediate grade (25) high-grade (3) non-Hodgkin's lymphoma and Hodgkin's disease (10). Based on clinical assessment, CT scan findings and biopsy, 100 nodal sites and 15 extra-nodal sites were deemed positive. FDG Co-PET was superior to GS in nodal site positivity rate (97%vs 79%, P < 0.0001). Compared with GS, FDG Co-PET detected 39 more abnormal sites in 22 patients (48%), of which 28 sites were validated by biopsy, CT and/or progress FDG Co‐PET scanning. There was only one proven false negative FDG site in the spleen. CT + FDG Co-PET led to upstaging in 2 patients (4%), compared to CT + GS. Conclusion: 

FDG Co-PET shows potential for providing an accurate means for pretreatment staging of lymphoma and can detect extra sites of disease activity compared to GS. (Intern Med J 2005; 35: 91–96)
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Keywords: 18F fluorodeoxyglucose; 67gallium scintigraphy; coincidence gamma camera positron emission tomography; lymphoma; positron emission tomography

Document Type: Research Article

Affiliations: 1: Department of Nuclear Medicine, PET and Ultrasound 2: Radiation Oncology 3: Medical Oncology 4: Epidemiology Unit, South-Western Sydney Area Health Service 5: Haematology, Liverpool Hospital

Publication date: 2005-02-01

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