If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

Assessment of early paraprotein response to vincristine-doxorubicin-dexamethasone chemotherapy may help guide therapy in multiple myeloma

$48.00 plus tax (Refund Policy)

Download / Buy Article:



Vincristine, doxorubicin and dexamethasone (VAD) are commonly used as the initial chemotherapy in myeloma patients prior to high-dose therapy and autologous stem cell transplantation. We reviewed monoclonal protein responses and survival of 62 patients treated in this way. Among patients with IgG paraprotein, achievement of at least 50% reduction in paraprotein after the first cycle of VAD correlated with significantly better event-free survival at 3 years, compared with those having less than 50% response. We postulate that early paraprotein response may be used to identify high risk patients. (Intern Med J 2004; 34: 576−578)

Keywords: autologous ­transplantation; multiple myeloma; paraprotein; prognostic factors

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1445-5994.2004.00689.x

Affiliations: Division of Haematology, Institute of Medical and Veterinary Science and Department of Clinical Haematology, Royal Adelaide Hospital, Adelaide, South Australia, Australia

Publication date: September 1, 2004

Related content



Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more