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Cladribine followed by autologous stem-cell transplantation in progressive multiple sclerosis

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We studied the safety of autologous peripheral blood stem-cell transplantation (PBSCT) in four patients with progressive multiple sclerosis. Clinical and magnetic resonance imaging outcomes were secondary end-points. Cladribine administration preceded filgrastim-primed PBSC collection, aiming for lymphocyte depletion. Conditioning was with antithymocyte globulin and cyclophosphamide. The procedure was well tolerated, but without obvious clinical benefit. The study was ­terminated when other therapeutic options with lower morbidity became available. (Intern Med J 2004; 34: 66−69)

Keywords: cladribine; stem-cell transplant;  multiple sclerosis

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1444-0903.2004.00516.x

Affiliations: 1: Bone Marrow Transplant Service and Departments of 2: Neurosciences and 3: Radiology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.

Publication date: January 1, 2004

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