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No association between serum levels of insulin-like growth factor-I, vascular endothelial growth factor, prolactin and clinicopathological characteristics of breast carcinoma after surgery

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Abstract:

Abstract Background: 

Angiogenesis is essential for tumour growth and metastasis. Vascular endothelial growth factor (VEGF) has been suggested as the major angio­genic factor in breast carcinoma. Both insulin-like growth factor-I (IGF-I) and prolactin are involved in the progression of breast cancer at least partly by stimulating angiogenesis. Aim:

The aim of the present study was to investigate the association between serum IGF-I, VEGF and prolactin levels and clinicopathological characteristics of breast carcinoma. Methods: 

Serum IGF-I, VEGF and prolactin levels were measured in breast cancer patients and controls and these levels were compared with well-known clinicopathological characteristics of breast carcinoma, including tumour size, axillary lymph node and oestrogen/progesterone receptor status, tumour grade and disease stage. Results: 

Serum prolactin, VEGF and IGF-I levels were found to be similar in breast cancer patients and control subjects (P > 0.05). When the patients were divided into groups according to their tumour size, axillary lymph node status, tumour grade, oestrogen/progesterone receptor status and disease stage, no significant differences in serum prolactin, VEGF and IGF-I levels were found among the groups (P > 0.05). Conclusions: 

The present study failed to demonstrate an association between serum levels of VEGF, IGF-I and prolactin and well-known clinicopathological characteristics of breast carcinoma. (Intern Med J 2004; 34: 310−315)

Keywords: breast cancer; insulin-like growth factor-I; prolactin; serum; vascular endothelial growth factor; ­angiogenesis

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1444-0903.2004.00591.x

Affiliations: 1: Biochemistry, 2: Medical Oncology, 3: Surgery, 4: Department of Surgery, Karaelmas University Medical School, Zonguldak, Turkey 5: Internal Medicine and 6: Public Health, Gazi University Medical School, Ankara and

Publication date: June 1, 2004

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