Management of brain metastases

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Solid tumour brain metastases are a frequent clinical dilemma for oncologists and general physicians. The sound management of brain metastases requires a multidisciplinary approach. In this review we discuss the diagnosis and management of brain metastases including the role of surgery, radiotherapy, and chemotherapy. The standard approaches of surgical excision and primary radiotherapy have evolved from randomised studies. However, controversies remain regarding post-surgery irradiation in the setting of a solitary metastasis and the role of palliative chemotherapy. (Intern Med J 2004; 34: 270−278)

Keywords: brain metastases; cerebral metastases; cranial irradiation; radiosurgery; ­radiotherapy

Document Type: Research Article


Affiliations: 1: Clinical Haematology and Medical Oncology and 2: Neurosurgery, Royal Melbourne Hospital and Departments of 3: Radiation Oncology, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia

Publication date: May 1, 2004

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