Evaluation of a warfarin initiation protocol for older people

$48.00 plus tax (Refund Policy)

Download / Buy Article:



A protocol for initiation of warfarin therapy, targeted specifically for older people and based on individual responses to initial warfarin doses, was evaluated in a case-control study. People within the protocol group: (i) received higher initial doses of warfarin, (ii) reached an international normalized ratio (INR) of 2 more quickly, (iii) spent more time with INR of 2−3 in the first week and (iv) were less likely to be over-anticoagulated. However, the proportion of people who reached an INR of 2 too quickly (in <4 days) was no greater. The protocol correctly predicted the maintenance dose range of warfarin in over 70% of cases. (Intern Med J 2003; 33: 465−467)

Keywords: aged; drug administration; warfarin administration and dosage; ­comparative study; ­warfarin adverse effects

Document Type: Research Article

DOI: http://dx.doi.org/10.1046/j.1445-5994.2003.00452.x

Affiliations: Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand

Publication date: September 1, 2003

Related content



Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more