What is the prognosis of mild normocytic anaemia in older people?
Source: Internal Medicine Journal, Volume 33, Numbers 1-2, January 2003 , pp. 14-17(4)
Abstract:Abstract Background: There is reduced survival for people with all types of anaemia and it has been shown that there is a low yield from investigations for older people with normocytic anaemia. However, the longer-term outcomes of people with mild normocytic anaemia are not known. Aims: To determine the 5-year prognosis of older people with mild normocytic anaemia, compared with non-anaemic controls. Methods: This was a prospective cohort study, with some retrospective data collection, comparing 52 people aged ≥65 years (haemoglobin 100−119 g/L; mean cell volume 80−99 fL) without an obvious cause at presentation with 52 non-anaemic controls. The incidence of death, new malignancies and significant illnesses was compared between the two groups, 5 years later. Results: Anaemic patients were less likely to be living at home at baseline. Although survival was lower for the anaemic group at all follow-up times, these differences were not significantly different. Over 5 years, there were no significant differences between groups in the types of problems that developed. Conclusions: A mild normocytic anaemia in older people, in the absence of an obvious cause, is not associated with significant differences in outcomes but is associated with poorer independence and a trend to lower survival. We suggest it may therefore be a marker of frailty in older people. (Intern Med J 2003; 33: 14−17)
Document Type: Research article
Publication date: 2003-01-01