Minidose (1 mg) warfarin as prophylaxis for central vein catheter thrombosis
Background: Central vein catheters, which are used in the treatment of cancer patients, are prone to thrombotic complications of the catheter or adjacent vein. Previous studies suggest that 1 mg warfarin daily (minidose) can significantly reduce that risk.
Aims: This study aims to establish whether minidose warfarin could reduce catheter-related thrombosis in adult patients with haematological malignancies.
Methods: Patients were randomly selected to receive warfarin or not. The end-points studied were: (i) occlusion by thrombus, (ii) removal of catheter for other reasons or (iii) 90 days free of thrombus.
Results: There was no significant difference in the incidence of catheter thrombosis or venous thrombosis and no significant variation in catheter survival between the study and control groups.
Conclusions: This study found no benefit of the routine use of minidose warfarin for prophylaxis of central vein catheter thrombosis in patients with haematolog- ical malignancies and therefore does not support the routine use of minidose warfarin for prophylaxis in such patients. (Intern Med J 2002; 32: 84–88)
Document Type: Research Article
Publication date: 2002-03-01