Increasing relevance of pharmacogenetics of drug metabolism in clinical practice

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Much of the individual variation in drug response is due to genetic drug metabolic polymorphisms. Clinically relevant examples include acetylator status; cytochrome P450 2D6, 2C9 and 2C19 polymorphisms; and thiopurine methyltransferase deficiency. It is important to be aware of which drugs are subject to pharmacogenetic variability. In the future, population-based pharmacogenetic testing will allow more individualized drug treatment and will avoid the current empiricism. (Intern Med J 2001; 31: 476–478)

Keywords: drug metabolism; pharmacogenetics; polymorphism

Document Type: Research Article

Publication date: November 1, 2001

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