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Towards a molecular approach to gastric cancer management

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Abstract

Gastric cancer is a leading cause of cancer death worldwide. Most patients with gastric cancer present with locally advanced and incurable disease, and overall survival is poor. Considerable research efforts towards the epidemiology and pathogenesis of gastric cancer have not been translated into treatment success. We discuss current concepts of the pathogenesis of gastric cancer and how recent research advances, in particular global gene expression strategies, may improve this understanding, and suggest a framework wherein these approaches may be used. (Intern Med J 2001; 31: 296–303)
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Keywords: cDNA microarray; expression analysis; gastric cancer; tumour array; tumour marker

Document Type: Research Article

Affiliations: 1: Peter MacCallum Cancer Institute, Melbourne, Victoria 2: Gastroenterology Unit, The Canberra Hospital, Canberra, Australian Capital Territory, Australia

Publication date: 2001-07-01

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