Is there another chapter in the Helicobacter pylori/peptic ulcer disease story?

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The role of Helicobacter pylori in the production of mucosal damage has largely been considered within a simple infection paradigm, because to date eradication has appeared to be a predictable outcome of antibiotic therapy. Changes in the epidemiology and management of peptic ulcer disease, however, require a more comprehensive framework to understand these shifting clinical patterns. The present review examines mucosal damage as an outcome of a complicated host–parasite relationship, with alterations in both parasite physiology and host defence mechanisms being keys to understanding disease patterns. (Intern Med J 2001; 31: 181–183)

Keywords: Helicobacter pylori; coccoid form; cytokine response; host-parasite relationship

Document Type: Research Article


Publication date: April 1, 2001

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