Significant relationship of time-dependent uroﬂowmetric parameters to lower urinary tract symptoms as measured by the International Prostate Symptom Score

Authors: ITOH, HIDEAKI; KOJIMA, MUNEKADO; OKIHARA, KOJI; UKIMURA, OSAMU; USHIJIMA, SO; KAWAUCHI, AKIHIRO; MIKI, TSUNEHARU

Source: International Journal of Urology, Volume 13, Number 8, August 2006 , pp. 1058-1065(8)

Publisher: Wiley-Blackwell

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Abstract:

Aims:

The aim of the present paper is to elucidate the possible involvement of time-dependent parameters as obtained by uroﬂowmetry in the manifestation of lower urinary tract symptoms (LUTS) in elderly patients. Methods:

Using simple and multiple regression analyses, the correlation of the International Prostate Symptom Score (IPSS) with objective parameters including age, postvoid residual, uroﬂowmetry and transrectal ultrasonic measurements of the prostate was analyzed in 206 male patients (average age of 68.0 ± 7.4 years) who visited our outpatient clinic complaining of LUTS. Results:

In the 206 patients, the mean maximum ﬂow rate was 12.2 mL/s (13.7 mL/s in mild, 11.9 mL/s in moderate, and 11.2 mL/s in severe IPSS total score) and average ﬂow rate was 4.4 mL/s (5.4 mL/s in mild, 4.3 mL/s in moderate, and 3.5 mL/s in severe IPSS total score). Simple regression analyses demonstrated that age, voiding time, and average and maximum ﬂow rates correlate significantly with symptom scores. In particular, relatively strong relationships were found between average ﬂow rate and scores of intermittency, weak stream and total and voiding symptoms scores. Serum prostate specific antigen level, postvoid residual and prostatic ultrasonic measurements did not show a significant correlation with symptom scores. Multiple regression analyses revealed age and average ﬂow rate to be independent determinants for symptom scores. Conclusion:

These results suggest that the time-dependent function in micturition interferes in the manifestation of LUTS in elderly men who have borderline or pathologic maximum ﬂow rate. When evaluating uroﬂowmetry in elderly male patients with LUTS, attention should be paid to time-dependent parameters such as voiding time and average ﬂow rate.

Keywords: benign prostatic hyperplasia; international prostate symptom score; lower urinary tract symptoms; uroﬂowmetry

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1442-2042.2006.01496.x

Affiliations: 1: Department of Urology, Kyoto Prefectural University of Medicine and

Publication date: 2006-08-01

Significant relationship of time-dependent uroﬂowmetric parameters to lower urinary tract symptoms as measured by the International Prostate Symptom Score

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