Tumor lysis syndrome after transcatheter arterial infusion of cisplatin and embolization therapy for liver metastases of melanoma

Authors: Nakamura, Yoshiyuki; Nakamura, Yasuhiro; Hori, Enmi; Furuta, Junichi; Ishii, Yoshiyuki; Takahashi, Takenori; Kawachi, Yasuhiro; Otsuka, Fujio

Source: International Journal of Dermatology, Volume 48, Number 7, July 2009 , pp. 763-767(5)

Publisher: Wiley-Blackwell

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Abstract:

Background

Tumor lysis syndrome (TLS) is rare in the treatment of solid tumors, but it may occur in myelolymphoproliferative diseases. Methods

A 58-year-old man with bulky metastatic melanoma of the liver was treated with transcatheter arterial infusion of cisplatin and embolization therapy. The patient developed classic signs of TLS within 24 h of chemotherapy, including acute renal failure. Results

The patient was treated with aggressive hydration, allopurinol, and repeated hemodialysis. He gradually improved and his biochemical markers returned to normal. Conclusion

TLS is an uncommon, but potentially life-threatening, complication in melanoma and other solid tumors. It is important for oncologists to recognize this complication and prevent its development if bulky metastatic disease and several pre-existing risk factors, such as multiple and bulky liver metastases, elevated lactate dehydrogenase, and hyperuricemia, are present.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1365-4632.2009.04087.x

Publication date: 2009-07-01