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The frequency of scarring after genital ulcers in Behçet's syndrome: a prospective study

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Abstract:

Abstract Background 

Although genital ulceration with or without scar formation is an important manifestation of Behçet's syndrome, formal data on the rate of genital scarring are lacking. Objective 

To study prospectively the frequency of genital scar formation after genital ulcers in patients with Behçet's syndrome. Methods 

One hundred and two patients (72 males and 30 females) with fresh genital ulcers presenting at a dedicated Behçet's syndrome outpatient clinic were followed for 6 weeks. The ulcer location, size, and frequency of scar formation were noted. All patients were treated with similar topical therapy. Results 

Two hundred and ten genital ulcers were followed in both sexes. The rate of scar formation was 66.2% (102/154) in male patients and 60.7% (34/56) in female patients. When genital ulcers were stratified as a function of size, large genital ulcers (≥ 1 cm in diameter) developed scars more frequently than did smaller ulcers (< 1 cm). The rate of scar formation in male patients with large genital ulcers was 89.4% (59/66) and with small ulcers was 48.9% (43/88) (P < 0.001). In females, all 19 large ulcers healed with scarring, and the same was true for 40.5% (15/37) of the small ulcers (2 = 18.61, P < 0.001). Conclusion 

About two-thirds of genital ulcers in Behçet's syndrome leave scars. The rate of scar formation depends on the ulcer size.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-4632.2006.02859.x

Publication date: May 1, 2006

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