Ivermectin: pharmacology and application in dermatology

Authors: Dourmishev, Assen L.; Dourmishev, Lyubomir A.; Schwartz, Robert A.

Source: International Journal of Dermatology, Volume 44, Number 12, December 2005 , pp. 981-988(8)

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Abstract:

Ivermectin is a synthetic derivative of the antiparasitic class of compounds known as avermectins. It is a macrolide endectocide with activity against both endoparasites with cutaneous tropism (Strongyloides stercoralis, Ancylostoma braziliense, Cochliomyia hominivorax, Dermatobia hominis, Filaria bancrofti, Wucheria malayi, Onchocerca volvulus, Loa-loa) and ectoparasites such as Sarcoptes scabies, Pediculus humanus, Demodex folliculorum, and Cheyletiella sp. Ivermectin is of great interest in the treatment of patients with different forms of scabies, head lice, demodecidosis, cutaneous larva migrans, cutaneous larva currens, myiasis, and filariasis.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1365-4632.2004.02253.x

Affiliations: 1: From the Department of Dermatology and Venereology, Medical University, Sofia, Bulgaria, and the Department of Dermatology, New Jersey Medical School, Newark, NJ

Publication date: 2005-12-01