The validity of a hyperventilation test for an investigation of autonomic failure: assessment in patients with multiple system atrophy and Parkinson's disease

Authors: DEGUCHI, K.1; SASAKI, I.1; IKEDA, K.1; SHIMAMURA, M.1; URAI, Y.1; TSUKAGUCHI, M.1; TOUGE, T.2; TAKEUCHI, H.3; KURIYAMA, S.1

Source: International Journal of Clinical Practice, Volume 60, Number 12, December 2006 , pp. 1542-1547(6)

Publisher: Blackwell Publishing

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:

Summary

Although heart rate (HR) responses to hyperventilation (HV) have been used as a cardiovascular autonomic function test, autonomic involvement during HV remains uncertain. To clarify the relationship between autonomic activity and cardiovascular changes during HV, we compared cardiovascular responses during HV among subjects with different autonomic function, namely 16 patients with probable multiple system atrophy (MSA), 16 with possible MSA, 28 with Parkinson's disease (PD) and 28 healthy controls. Abnormalities of cardiovascular responses to head-up postural change and the Valsalva maneuver were definitely present in the order of probable MSA, possible MSA and PD, and abnormal HR and blood pressure (BP) responses during HV were observed in probable MSA and possible MSA, but not in PD. Unlike the significant difference in standard cardiovascular autonomic function tests, the HR and BP responses during HV were equivalent between probable and possible MSA. These findings suggest that cardiovascular control during HV may be affected not only by autonomic activity but also by other factors.

Keywords: Hyperventilation; hypocarbia; autonomic nervous system; multiple system atrophy; orthostatic hypotension; heart rate; blood pressure

Document Type: Research article

DOI: 10.1111/j.1742-1241.2005.00802.x

Affiliations: 1: Department of Health Sciences 2: Kagawa University Faculty of Medicine, Miki-cho, Kita-gun, Kagawa University 3: Takamatsu-shi, Kagawa, Japan

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$50.39 plus tax      Refund Policy

 

OR

Back to top

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages.
Page Help Click here for Page Help
Shopping cart
Tools
Sign in






Need to register?
Sign up here
Text size: A | A | A | A