Authors: RIZZOLI, R.¹; EISMAN, J. A.²; NORQUIST, J.³; LJUNGGREN, Ö.⁴; KRISHNARAJAH, G.³; LIM, S-K⁵; CHANDLER, J.³

Source: International Journal of Clinical Practice, Volume 60, Number 8, August 2006 , pp. 1013-1019(7)

Publisher: Wiley-Blackwell

Abstract:

Summary

A serum 25-hydroxyvitamin D [25(OH)D] level of 75 nmol/l (30 ng/ml) has been proposed as the minimum for adequate vitamin D nutrition as lower levels are associated with increases in serum parathyroid hormone in otherwise healthy adults. Amongst 2589 community-dwelling, postmenopausal women with osteoporosis from 18 countries, recruited to determine risk factors for vitamin D inadequacy, 64% had vitamin D inadequacy. General health, education, ethnicity, sun exposure, skin reactivity, diet, recent travel to sunny climates, vitamin D supplementation, body mass index (BMI), season and latitude were assessed using logistic regression models. Asian ethnicity, BMI ≥30 kg/m², living in non-equatorial countries, inadequate vitamin D supplementation, poor/fair health, no education about vitamin D, skin reactivity and no recent travel to sunny areas were significant predictors. Several modifiable risk factors are associated with vitamin D inadequacy worldwide, suggesting potentially simple ways to increase vitamin D and improve bone health in postmenopausal women.

Keywords: 25-Hydroxyvitamin D; inadequacy; osteoporotic; postmenopausal; risk factors; vitamin D

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1742-1241.2006.01066.x

Affiliations: 1: Hopital Cantonal Universitaire de Geneve, Geneva, Switzerland 2: Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent's Hospital and University of New South Wales, Sydney, NSW, Australia 3: Epidemiology, Merck Research Laboratories, North Wales, PA, USA 4: Department of Medical Sciences, University Hospital, Uppsala, Sweden 5: Severance Hospital Department of Internal Medicine, Seoul, Korea

Publication date: 2006-08-01

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