Earlier intervention in type 2 diabetes: The case for achieving early and sustained glycaemic control

Authors: Bailey, C. J.¹; Prato, S. Del²; Eddy, D.³; Zinman, B.⁴

Source: International Journal of Clinical Practice, Volume 59, Number 11, November 2005 , pp. 1309-1316(8)

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Abstract:

Summary

In type 2 diabetes, the onset and progression of complications is significantly delayed by improving glycaemic control. However, the proportion of patients reaching and sustaining guideline recommendations for glycaemic targets remains unacceptably low. Recent clinical trials and predictive physiologically based mathematical simulations (Archimedes model) indicate that benefits can be enhanced with earlier intervention and timely achievement of glycaemic targets. This article reviews the evidence for early intervention, showing that intensive approaches, including earlier introduction of combination therapy, allow more patients to achieve glycaemic targets and hence reduce complications and delay disease progression.

Keywords: Type 2 diabetes; glycaemic control; Archimedes model; early intervention; combination therapy

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1742-1241.2005.00675.x

Affiliations: 1: Birmingham, UK, University of Pisa, 2: Pisa, Italy, The Archimedes Project, 3: Oakland, CA, USA, Mount Sinai Hospital, 4: University of Toronto, Toronto, Canada

Publication date: 2005-11-01