Comparison of the efficacy and tolerability of telmisartan 40 mg vs. enalapril 10 mg in the treatment of mild-to-moderate hypertension: a multicentre, double-blind study in Taiwanese patients

Authors: Chen, J-H.¹; Cheng, J-J.²; Chen, C-Y.³; Chiou, H-C.⁴; Huang, T-Y.⁵; Tsai, C-D.⁶; Fu, M.M-Y.⁷; Cherng, W-J.⁸

Source: International Journal of Clinical Practice, Volume 58, Supplement 145, December 2004 , pp. 29-34(6)

Publisher: Blackwell Publishing

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Abstract:

Summary

The purpose of this randomised, double-blind, double-dummy, parallel-group study was to evaluate the efficacy and tolerability of telmisartan 40 mg once daily vs. enalapril 10 mg once daily in 147 Taiwanese patients with mild-to-moderate essential hypertension (diastolic blood pressure [DBP] 90-109 mmHg). After 6 weeks' treatment, telmisartan produced a significantly greater reduction from baseline in the primary endpoint of trough seated DBP compared with enalapril 10 mg (11.7 vs. 8.7 mmHg, respectively; p = 0.02). Numerically greater reductions compared with baseline in seated systolic blood pressure (SBP), standing DBP, and standing SBP were achieved with telmisartan compared with enalapril. Also, numerically greater proportions of patients achieved blood pressure control (DBP/systolic blood pressure [SBP] <90/140 mmHg) and responded to treatment (reduction from baseline in trough seated DBP ≥10 mmHg and/or post-treatment DBP <90 mmHg; reduction from baseline in trough seated SBP ≥10 mmHg and/or post-treatment SBP <140 mmHg) with telmisartan 40 mg compared with enalapril 10 mg. Although both treatments were well tolerated, the incidence of cough was markedly lower with telmisartan 40 mg (8.5%) than with enalapril 10 mg (18.4%) in this population of Taiwanese hypertensive patients.

Keywords: Telmisartan; angiotensin II receptor blocker; enalapril; angiotensin-converting enzyme inhibitor; antihypertensives; hypertension

Document Type: Research article

DOI: 10.1111/j.1742-1241.2004.00407.x

Affiliations: 1: Department of Internal Medicine, National Cheng Kung University Hospital, Tainan 2: Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 3: Department of Internal Medicine, Chia Yi Christian Hospital, Chia Yi 4: Department of Internal Medicine, Cathay General Hospital, Taipei 5: Department of Internal Medicine, Chi-Mei Medical Center, Tainan 6: Department of Internal Medicine, Changhua Christian Hospital, Changhua 7: Department of Internal Medicine, Chang-Gung Memorial Hospital, Kaohsiung 8: Department of Internal Medicine, Chang-Gung Memorial Hospital, Keelung, Taiwan

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