Rh iso-immunisation with syndrome of hepatocellular damage. An unusual presentation with review of literature

Authors: A. Thaplial¹; U. Ramachandran¹; K.K. Sharma¹; P. Gautam¹; N. Sarkar¹

Source: International Journal of Clinical Practice, Volume 58, Number 11, November 2004 , pp. 1056-1060(5)

Publisher: Blackwell Publishing

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Abstract:

Summary

Rh iso-immunisation is prevalent in many underdeveloped countries. Severe haemolytic anaemia with or without hydrops fetalis, dangerous level of haemolytic unconjugated bilirubin and imminent bilirubin encephalopathy are the hallmarks of haemolytic disease of the newborn. The investigative protocols and efficient management of this entity are adequately described in literature. An unusual manifestation of this disease with severe hepatocellular damage and conjugated hyperbilirubinemia was noticed in a neonate. The literature has been reviewed and the specific symptom complex has been attributed to ‘syndrome of hepatocellular damage’, which is a rare accompaniment of haemolytic disease of the newborn. Attempts have been made to describe the syndrome in detail, with latest reference regarding complete workup and management. Few useful tips for prevention of the disease in a community background have been suggested.

Keywords: Haemolytic disease of newborn; exchange transfusion; intravenous immunoglobulin; syndrome of hepatocellular damage

Document Type: Research article

DOI: 10.1111/j.1742-1241.2004.00069.x

Affiliations: 1: The Department of Pediatrics, Manipal College of Medical Sciences, Pokhara, Nepal

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