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Treatment of human head lice infestations in a single application with a new galenic lotion

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Abstract:

Synopsis To evaluate the efficiency and safety of a new galenic meta-emulsion for the treatment of human head lice () in a single application. A controlled clinical study was conducted comparing lice infestation and nit hatching observed before and after a treatment in a single application. Eighty-two of the 87 children included completed the study. An infestation control was performed on 36 and 46 children, 8 and 24 h respectively after application. Five days later, a meticulous hair examination was carried out to check that the lice infestation was completely cured. After a single application of the lotion being tested, an examination of the scalp with a head lice detection comb, as well as an examination of the rinsing water and the towel used for drying after washing, showed that out of the total 1285 lice, there were no live lice. The percentage of nits hatching before treatment was close to 70%. In comparison, after an 8-h treatment (), the percentage of nits hatching was 2.1%, with only 0.35% of living nymphs. After a 24-h treatment (), 1.9% hatched with 0.38% living nymphs. Nymphs were revealed to be non-viable. After 5 days (), no living adult or immature lice were found on the subjects tested. Moreover, observation of tolerance levels to this treatment at days 1, 5 and 12 showed no side effects. The specific galenic lotion completely cured head lice infestation in the population studied in a single application. The lotion, a patented meta-emulsion, has a mechanical action that asphyxiates lice and nits. Considering the advantages of the single application, the possibility of complete concomitant therapeutics for a whole school population within only 1 day and the high level of tolerance to this treatment, this approach seems simple and promising.

French
Résumé

Évaluer l’efficacité en une seule application et la tolérance d’une nouvelle méta-émulsion spécifiquement adaptée au traitement de la pédiculose (Pediculus capitis). Une étude clinique contrôlée a été conduite afin de comparer le degré d’infestation par les poux, ainsi que le taux d’éclosion des lentes, avant et après un traitement en une seule application. Sur les 87 sujets inclus, 82 ont complété l’étude. Une évaluation du taux d’infestation a été faite 8 heures après l’application chez 36 sujets et 24 heures après chez les 46 autres. Cinq jours plus tard, un examen méticuleux du cuir chevelu a été effectué pour confirmer la guérison complète de la pédiculose. Après une seule application de la lotion testée, l’examen du cuir chevelu ainsi que le comptage dans les eaux de rinçage et sur les serviettes de séchage après lavage des cheveux, ont montré un total de 1285 poux éliminés. Aucun de ces poux n’était vivant. Concernant les lentes, le pourcentage d’éclosion avant traitement était proche de 70%. Après 8 heures de traitement (t +8), le taux d’éclosion était de 2.1% dont 0.35% de larves vivantes. Après un traitement de 24 heures (t +24), seul 1.9% des lentes a éclos dont 0.38% de larves vivantes. Les larves se sont révélées non-viables. Après 5 jours (t +120), aucun pou adulte ou immature n’a été retrouvé chez les sujets étudiés. En outre, l’observation de la tolérance aux jours 1, 5 et 12, n’a révélé aucun effet indésirable. La lotion testée a permis de guérir complètement les sujets de la pédiculose, en une seule application. La méta-émulsion brevetée agit de manière mécanique en asphyxiant les poux et les lentes. En considérant l’avantage de l’application unique et de la bonne tolérance au traitement, les résultats semblent prometteurs.

Keywords: Pediculus capitis; asphyxiating action; clinical trial; head lice; nits operculum

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1468-2494.2009.00558.x

Affiliations: 1: School of Veterinary Medicine, University of Ceará, Fortaleza, Brazil 2: School of Medicine, University of Ceará, Fortaleza, Brazil 3: Centre of Anti-Parasitological Product Studies, Tours, France 4: Department of Parasitology, Marie-Louise Research Laboratory, Belgium

Publication date: October 1, 2010

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