The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia

Authors: Pemberton, LA¹; Stone, E²; Price, P; van Bockxmeer, F²; Brew, BJ

Source: HIV Medicine, Volume 9, Number 8, September 2008 , pp. 677-680(4)

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Abstract:

Objectives

Host genetic factors implicated in AIDS dementia complex (ADC) were studied. Methods

DNA from ADC patients (n=56), unselected HIV-seropositive patients (n=112, 171, 185 and 204) and HIV-seronegative controls (n=204, 60, 60, 96 and 624) were typed for polymorphic loci in genes encoding tumour necrosis factor (TNF)-α, interleukin (IL)-1α, IL-1β, IL-12 and Apolipoprotein E (ApoE). Diagnosis of ADC was based on neurological symptoms, signs and neuroimaging findings with other causes of dementia excluded. Patients selected had ADC stage ≥1 and CD4 counts of <500 cells/μL. Results

Allele 2 of TNFA-308 was more common in ADC patients compared to HIV-positive or HIV-negative controls (P=0.005, 0.024). No other differences between ADC patients and control groups were significant. Meta-analyses confirmed these results. Conclusions

This study suggests that TNFA-308 allele 2 or an allele in linkage disequilibrium with this locus influences ADC.

Keywords: ApoE; HIV-1 associated dementia; IL-1; polymorphisms; TNF-α

Document Type: Short communication

DOI: http://dx.doi.org/10.1111/j.1468-1293.2008.00614.x

Affiliations: 1: Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia, 2: Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, WA, Australia,

Publication date: 2008-09-01