Effect of early initiation of highly active antiretroviral therapy on CD4 cell count and HIV-RNA viral load trends within 24 months of the onset of acute retroviral syndrome

Authors: Voirin, N; Routy, J-P¹; Smith, D²; Baratin, D³; Trépo, C; Cotte, L; Touraine, J-L⁴; Livrozet, J-M⁴; Cooper, DA²; Ritter, J; André, P; Vanhems, P

Source: HIV Medicine, Volume 9, Number 6, July 2008 , pp. 440-444(5)

Publisher: Wiley-Blackwell

Abstract:

Objectives

The effect of starting highly active antiretroviral therapy (HAART) early after the onset of acute retroviral syndrome (ARS) on CD4 and HIV-RNA trends was studied over a 2-year follow-up period. Methods

Four groups of HIV-infected patients stratified according to the time interval from ARS onset to HAART initiation and a control group of untreated patients were compared. Results

The results indicated that the earlier the start of HAART, the faster was the rate of CD4 increase and HIV-RNA decrease. However, this difference did not seem to persist at 24 months. Conclusions

The optimal treatment strategy for HIV-infected patients needs to be explored further.

Keywords: acute disease; CD4 lymphocyte count; highly active antiretroviral therapy; HIV infections; viral load

Document Type: Short communication

DOI: http://dx.doi.org/10.1111/j.1468-1293.2008.00576.x

Affiliations: 1: Immunodeficiency Service and Division of Hematology, McGill University Health Centre, Montreal, Quebec, Canada, 2: National Centre in HIV Epidemiology and Clinical Research, New South Wales University, Sydney, Australia, 3: Department of Hygiene, Epidemiology and Prevention, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France, 4: Transplantation and Clinical Immunology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France and

Publication date: 2008-07-01

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• In this Subject: Allergy & Immunology ,  Internal Medicine ,  Pediatrics
• By this author: Voirin, N ;  Routy, J-P ;  Smith, D ;  Baratin, D ;  Trépo, C ;  Cotte, L ;  Touraine, J-L ;  Livrozet, J-M ;  Cooper, DA ;  Ritter, J ;  André, P ;  Vanhems, P

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