Antiretroviral drug resistance among antiretroviral-naïve persons with recent HIV infection in Thailand

Authors: Apisarnthanarak, A¹; Jirayasethpong, T²; Sa-nguansilp, C³; Thongprapai, H³; Kittihanukul, C³; Kamudamas, A⁴; Tungsathapornpong, A⁵; Mundy, LM⁶

Source: HIV Medicine, Volume 9, Number 5, May 2008 , pp. 322-325(4)

Publisher: Wiley-Blackwell

Abstract:

Objectives

To evaluate the prevalence and patterns of antiretroviral (ARV) drug resistance (ARV-DR) among ARV drug-naïve, recently infected persons with HIV in the 4-year interval (2003-2006) after the inception of the National Access to ARV Programme for People who have AIDS in Thailand. Methods

Cross-sectional study of patients with recent HIV infection for HIV risks, ARV-DR risks and baseline ARV-DR. Results

Seven of the 305 patients (2%) had baseline ARV-DR. Via contract tracing, all seven patients with transmitted ARV-DR identified sexual partners with prior ARV treatment failure and had documented low (<75%) ARV adherence. Annual ARV-DR increased from 0 to 5.2% (P=0.06) between 2003 and 2006. Conclusions

Report of sexual partners with potential HIV and ARV drug exposures can prompt baseline ARV-DR testing of at-risk individuals, while behavioural interventions for adherence and safer sex are refined to minimize the emergence of resistance to generic, fixed-dose combination stavudine, lamivudine and nevirapine (GPO-VIR) therapy.

Keywords: antiviral drug resistance; drug-naïve; HIV; recent infection; Thailand

Document Type: Short communication

DOI: http://dx.doi.org/10.1111/j.1468-1293.2008.00562.x

Affiliations: 1: Department of Medicine, Division of Infectious Diseases, Thammasat University Hospital, Pratumthani, Thailand, 2: Division of Infectious Diseases, Rajvithee Hospital, Bangkok, Thailand, 3: Health Concept International Ltd., Pratumthani, Thailand, 4: Division of Obstetrics and Gynaecology, Thammasat University Hospital, Pratumthani, Thailand, 5: Paediatric Division, Thammasat University Hospital, Pratumthani, Thailand and 6: Department of Public Health and St Louis University School of Public Health, St Louis, MO, USA

Publication date: 2008-05-01

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• In this Subject: Allergy & Immunology ,  Internal Medicine ,  Pediatrics
• By this author: Apisarnthanarak, A ;  Jirayasethpong, T ;  Sa-nguansilp, C ;  Thongprapai, H ;  Kittihanukul, C ;  Kamudamas, A ;  Tungsathapornpong, A ;  Mundy, LM

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