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Paratesticular liposarcoma with smooth muscle differentiation mimicking angiomyolipoma

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To discuss the differential diagnosis of a case of well-differentiated liposarcoma which had areas resembling angiomyolipoma—a feature which, to our knowledge, has not been reported previously. Methods and results

A tumour in the paratesticular region had apparently been present for 40 years, but had grown recently. A fat component containing lipoblasts was admixed with areas resembling angiomyolipoma, i.e. desmin positive, but HMB45-negative smooth muscle proliferation with atypia and thick-walled blood vessels devoid of elastin. Conclusion

The diagnosis of liposarcoma, rather than angiomyolipoma with adipose atypia, in this case is based on the fact that smooth muscle differentiation is documented in liposarcoma, lack of HMB45 staining and recent clonality studies which suggest that the fat in angiomyolipoma is not neoplastic.
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Keywords: angiomyolipoma; atypia; liposarcoma; paratesticular location

Document Type: Original Article

Affiliations: 1: Department of Histopathology/Cytology 2: Urology, Peterborough Hospitals NHS Trust 3: Department of Histopathology, Royal Marsden NHS Trust, London, UK

Publication date: 01 March 2000

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