MIB-1 proliferation index correlates with survival in pleural malignant mesothelioma

Authors: Comin¹; Anichini¹; Boddi²; Novelli¹; Dini¹

Source: Histopathology, Volume 36, Number 1, January 2000 , pp. 26-31(6)

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Abstract:

Aims

The purpose of this study was to establish whether the cell proliferation index assessed by the monoclonal antibody MIB-1 would correlate with survival in pleural malignant mesothelioma. Methods and results

We studied a series of seven long-term survivors with pleural malignant mesothelioma and a group of control cases with short-term survival. All cases showed MIB-1 positive cells, and labelling indices were expressed as percentage of cells with positive nuclear immunostaining by randomly counting 1000 tumour cells. A statistically significant difference was found between MIB-1 values in the long-term survival group and the control cases with short-term survival. Conclusions

Our results indicate that the differences in biological behaviour of malignant mesothelioma in long-term and short-term survivors may be explained in part by differences in tumour growth fraction and that proliferation index could represent an important prognostic parameter for this tumour.

Keywords: immunohistochemistry; mesothelioma; MIB-1; prognosis; survival

Document Type: Original article

DOI: http://dx.doi.org/10.1046/j.1365-2559.2000.00793.x

Affiliations: 1: Istituto di Anatomia e Istologia Patologica, Università degli Studi di Firenze 2: Dipartimento di Patologia e Oncologia Sperimentali, Università degli Studi di Firenze, Italy

Publication date: 2000-01-01