Refractory Migraine and Chronic Migraine: Pathophysiological Mechanisms

Authors: Goadsby, Peter J.; Hargreaves, Richard

Source: Headache: The Journal of Head and Face Pain, Volume 48, Number 9, October 2008 , pp. 1399-1405(7)

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Abstract:

Despite increased understanding of primary headaches and their treatment, the underlying causes of refractory migraine remain unknown. This note considers potential genetic, structural, functional and pharmacological factors that could contribute to this relatively intractable condition. Further understanding of refractory migraine will require the use of medical imaging technologies, clinical experimental medicine studies on novel pharmacological agents and astute observations in clinical practice to direct potential novel therapeutic approaches.

Keywords: migraine; brain; trigeminal

Document Type: Erratum

DOI: http://dx.doi.org/10.1111/j.1526-4610.2008.01274.x

Publication date: 2008-10-01