IngentaConnect Open-Label Trial of Cinnarizine in Migraine Prophylaxis

Authors: Togha, Mansooreh; Ashrafian, Hossein; Tajik, Parvin

Source: Headache: The Journal of Head and Face Pain, Volume 46, Number 3, March 2006 , pp. 498-502(5)

Abstract:

Objective.—To assess the effectiveness and safety of cinnarizine as a migraine-preventive therapy.

Methods.—Sixty patients with more than 2 migraine headache attacks during a 4-week baseline entered the study and received a 25-mg tablet cinnarizine twice daily for the first 3 days and then 3 times daily. They were assessed on weeks 2, 6, 10, and 14. Reduction from baseline in 4-week migraine headache rate was the primary efficacy variable. Reduction in migraine attacks duration and severity was also evaluated.

Results.—The mean reduction in 4-week migraine headache rate was 4.6 ± 2.2 from the baseline of 6.2 ± 2.2 after 14 weeks of treatment, which was statistically significant (P < 0.001). Percent reduction in 4-week migraine frequency was 35% after 2 weeks, 74% after 6 weeks, 74% after 10 weeks, and 75% after 14 weeks of treatment. Significant reduction in attack duration (P < 0.001) and severity (P < 0.001) was also noted. No serious adverse events were observed in this series of patient.

Conclusion.—Cinnarizine is an efficacious and well-tolerated prophylactic antimigraine medication, which has early onset effectiveness.

(Headache 2006;46:498-502)

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