Chronic Paroxysmal Hemicrania and Hemicrania Continua: Lack of Efficacy of Sumatriptan
There was a mild, but statistically significant reduction in visual analog scale values for headache intensity in hemicrania continua (P=0.04, Wilcoxon). There was no clear, ie, clinically meaningful, reduction in visual analog scale values in any particular patient with hemicrania continua. Taken together, these results seem to show that sumatriptan is of no benefit in chronic paroxysmal hemicrania, but may have a partial efficacy in hemicrania continua. However, the latter effect is clinically unimportant This minor difference in regard to the clinical effect may, nevertheless, be of some interest pathogenetically, indicating minor differences between the two headaches. The lack of sumatriptan effect in chronic paroxysmal hemicrania clearly and markedly strengthens the nonalignment concept in regard to chronic paroxysmal hemicrania and cluster headache.
Document Type: Research Article
Affiliations: 1: Hospital N.S. Sonsoles, Avila, Spain (Drs. Pareja and Caminero). 2: Department of Neurology, Regionsykehuset I Trondheim, Trondheim University Hospital, Norway (Drs. Antonaci, Pareja, and Sjaastad); and the
Publication date: 1998-03-01