Skip to main content

Prevalence of Hepatitis (A–E) and HTLV-I/II Infection Markers in Hemodialysis Patients of Central Greece

Buy Article:

$51.00 plus tax (Refund Policy)



The aim of this study was to assess the prevalence of serological and molecular markers of hepatitis (A–E) and human T-lymphotropic viruses (HTLV) in hemodialysis (HD) patients of central Greece. Methods: 

370 patients (246 males, 60 ± 14 years) attending the renal units (RUs) of central Greece (n = 5) were tested for anti-HAV IgG, hepatitis B virus markers, anti-HCV, anti-HEV, and anti-HTLV-I/II with ELISA. In 131 casual samples, regardless of anti-HCV status, a sensitive, qualitative HCV-RNA assay (Versant®, Bayer) based on transcription-mediated amplification (TMA) was applied. Results: 

Previous HBV infection (anti-HBc) was found in 48% and current HBV infection in 5.5% (HbsAg) of the patients. Anti-HAV was detected in 94% while anti-HDV and anti-HTLV were negative. Anti-HCV prevalence was 23% varying from 11 to 36% in the different RUs. Frequency of anti-HEV (4.1%) was also highly varying (1.4–9.8%). There was no association between the infection markers and age, sex, or history of transfusion. Anti-HCV correlated with duration of HD. HCV-RNA was detected in 44/131 samples. In 15 cases results of anti-HCV and TMA were contradicting. Two anti-HCV negative samples were HCV-RNA positive (2.3%). Conclusion: 

In RUs of central Greece, a high prevalence of HCV infection was found, associated with the duration of HD. The high prevalence of anti-HEV found in 1 RU must be investigated further. In some of anti-HCV-negative patients viremia was detected. This result indicates that a considerable number of HCV infections are serologically occult. HCV-RNA testing, regardless of the anti-HCV status, has to be considered seriously in HD patients.

Document Type: Research Article


Affiliations: 1: Division of Nephrology and Department of Internal Medicine, School of Medicine, University Thessaly, Larissa 2: Blood Bank at the University Hospital of Ioannina, Greece.

Publication date: January 1, 2004

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more