Skip to main content

Estimation of Internal Filtration Flow Rate in a Dialyzer by a Doppler Ultrasonography

Buy Article:

$51.00 plus tax (Refund Policy)


Several types of dialyzers with enhanced internal filtration have been introduced in order to increase solute clearance, especially in relatively larger molecular solutes. In these dialyzers, enhanced internal filtration increased convective transport of the solute in addition to diffusive transport. The internal filtration flow rate (QIF) has not, however, been measured in clinical situations, because none of monitoring techniques can measure this value. Herein, the QIF value was estimated during an experimental and an analytical study. Namely, we measured blood flow velocity in a cross-sectional plane of the dialyzer by pulse Doppler ultrasonography. An in vitro study with bovine blood was carried out to determine the local blood flow velocity profile with a newly designed probe slider that enables parallel movement of the probe along the dialyzer. Furthermore, an analytical model was newly introduced to calculate changes in flow rate and pressure of blood and dialysate streams and solute concentrations along the dialyzer. The QIF value could be estimated by a simulation analysis to the experimental data using the analytical model.

Document Type: Research Article


Affiliations: 1: Department of Blood Purification, Kidney Center, Tokyo Women's Medical University 2: Nipro Corporation, Tokyo, Japan.

Publication date: January 1, 2004


Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more