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Is There Any Relationship between Serum Levels of IL-10 and Atherosclerosis in Hemodialysis Patients?

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Cardiovascular complications due to atherosclerosis (AS) are the major cause of mortality in hemodialysis (HD) patients. Inflammation may play an important role in the development of AS. Several studies have demonstrated the association of acute-phase proteins and cytokines with AS in the general population and in HD patients. Interleukin-10 (IL-10) is an anti-inflammatory cytokine. The aim of study was to compare serum levels inflammatory and anti-inflammatory indicators in HD patients according to the presence or absence of AS. Methods: 

Thirty-three HD patients were enrolled. AS was defined as the detection of plaques by Doppler ultrasonography. The patients were subgrouped according to the presence or absence of plaques. Serum levels of IL-1, IL-2, IL-6, IL-10, C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α) were measured. The factors for AS such as age, gender, hypertension, hyperlipidemia, and HD duration were also evaluated. Results: 

We found that the patients with AS had significantly higher hs-CRP and lower IL-10. Blood pressure values were also increased in patients with AS. Additionally, there was an increased correlation between CRP and IL-10. Conclusions: 

AS(+) patients undergoing HD had low serum levels of anti-inflammatory cytokine IL-10 and high serum levels of hs-CRP. These results may suggest that the limitation of anti-inflammatory response in atherosclerotic uremic patients is a triggering or contributing factor for AS.

Document Type: Research Article


Affiliations: 1: Department of Nephrology 2: Department of Radiology 3: Department of Biochemistry 4: Department of Biostatistics, Cukurova University, Adana, Turkey.

Publication date: January 1, 2004


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