Pre- and Post Hemodialysis Procalcitonin Levels and Their Relationships with Immunoregulatory, Proinflammatory Cytokines in Chronic Hemodialysis Patients
Procalcitonin (PCT) has been described as a new marker of severe infection and sepsis. In this study, we investigated the serum levels of PCT during the hemodialysis (HD) in chronically hemodialyzed patients and whether the PCT levels were correlated with other cytokines. Methods:
We measured pre- and post-HD PCT, interleukin (IL-1), IL-2, IL-6, IL-10, tumor necrosis factor-α (TNF-α) concentrations in 24 stable patients undergoing chronic HD [11 males and 13 females; age 41.2 ± 18.0 years, 12 h/week, with a Kt/V of 1.41 ± 0.35, polysynthane (PSN) membrane being used in all patients, without reuse]. Pre- and post-HD PCT concentrations were compared with cytokines such as IL-1, IL-2, IL-6, IL-10, TNF-α, and clinical parameters including age, blood pressure, leukocyte, hemoglobin levels, C-reactive protein (CRP), epoetin (EPO) doses, BUN, creatinine, parathormone (PTH), ferritin, and transferrin levels. Results:
Pre- and post-HD serum PCT levels were similar (0.77 ± 0.40 and 0.83 ± 0.61 ng/mL), and higher than upper normal level of 0.5 ng/mL. The levels of IL-2 and IL-10 decreased and the levels of IL-1 and TNF-α increased. Post-HD PCT correlated with PTH, IL-1, IL-2, and IL-10. Conclusion:
About 60% of patients had elevated PCT levels, HD with low-flux PSN membrane did not change serum PCT and IL-6. While IL-1 and TNF-α increased, IL-2 and IL-10 decreased by PSN membrane during HD. So that PCT levels can be measured just after HD as do prior to start of HD. Is there any relationship between PCT and PTH? PCT may be important in uremic bone disease.
Document Type: Research Article
Publication date: January 1, 2004