Skip to main content

Pre- and Post Hemodialysis Procalcitonin Levels and Their Relationships with Immunoregulatory, Proinflammatory Cytokines in Chronic Hemodialysis Patients

Buy Article:

$43.00 plus tax (Refund Policy)


Procalcitonin (PCT) has been described as a new marker of severe infection and sepsis. In this study, we investigated the serum levels of PCT during the hemodialysis (HD) in chronically hemodialyzed patients and whether the PCT levels were correlated with other cytokines. Methods: 

We measured pre- and post-HD PCT, interleukin (IL-1), IL-2, IL-6, IL-10, tumor necrosis factor-α (TNF-α) concentrations in 24 stable patients undergoing chronic HD [11 males and 13 females; age 41.2 ± 18.0 years, 12 h/week, with a Kt/V of 1.41 ± 0.35, polysynthane (PSN) membrane being used in all patients, without reuse]. Pre- and post-HD PCT concentrations were compared with cytokines such as IL-1, IL-2, IL-6, IL-10, TNF-α, and clinical parameters including age, blood pressure, leukocyte, hemoglobin levels, C-reactive protein (CRP), epoetin (EPO) doses, BUN, creatinine, parathormone (PTH), ferritin, and transferrin levels. Results: 

Pre- and post-HD serum PCT levels were similar (0.77 ± 0.40 and 0.83 ± 0.61 ng/mL), and higher than upper normal level of 0.5 ng/mL. The levels of IL-2 and IL-10 decreased and the levels of IL-1 and TNF-α increased. Post-HD PCT correlated with PTH, IL-1, IL-2, and IL-10. Conclusion: 

About 60% of patients had elevated PCT levels, HD with low-flux PSN membrane did not change serum PCT and IL-6. While IL-1 and TNF-α increased, IL-2 and IL-10 decreased by PSN membrane during HD. So that PCT levels can be measured just after HD as do prior to start of HD. Is there any relationship between PCT and PTH? PCT may be important in uremic bone disease.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Research Article

Affiliations: 1: Department of Nephrology 2: Central Laboratory of Immunology and Microbiology 3: Department of Microbiology, Cukurova University, Adana, Turkey.

Publication date: 01 January 2004

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more