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Survival of End-Stage Renal Disease Diabetic Patients on Hemodialysis

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Abstract:

Purpose: 

To analyze survival and causes of mortality in end-stage renal disease (ESRD) diabetic patients treated by hemodialysis. Methods: 

Data of 1203 ESRD hemodialyzed patients between 1975 and 2002 were analyzed, 116 patients were excluded and 1087 patients included in the study. We studied the prevalence of the diabetic nephropathy, the rate of survival and causes of death by comparing diabetic patients with a control group of patients without diabetes. Results: 

Among the 1087 patients requiring dialysis, 272 (25%) were diabetic and 815 non-diabetic whose causal nephropathy was nephroangiosclerosis 32%, glomerulonephritis 15%, chronic interstitial nephropathy 14%, and others 14%. The diabetics were older at the beginning of dialysis than non-diabetic patients: 60.33 ± 11.39 years vs. 52.23 ± 17.20 years, p < 0.001. Average time on dialysis is more important in non-diabetic than diabetic group [5.90 ± 5.73 years vs. 2.71. ± 2.48 years, p < 0.001]. The rate of death was higher in diabetics than in control group [71.7% vs. 55.8%, respectively, p < 0.003]. The difference in survival between the two groups remains significant for the same age. Death caused by cardiovascular disorders is higher in diabetics (68.8%) than non-diabetics (31.2%) (p < 0.05). Among death causes, stroke is the most frequent cause in diabetics (18.4% vs. 11.6%) in non-diabetics, p < 0.05. Death by heart failure and infections is higher in diabetics but the difference is not statistically significant (12.3% in diabetics vs. 9.4% in non-diabetics for heart failure and 13.8% vs. 11.4% for infections). Death due to neoplasms is higher in non-diabetics (4.39% vs. 1.02% in diabetics, p < 0.05). Conclusion: 

In our cohort, mortality in diabetic patients is higher than in non-diabetic patients. Cardio-vascular disorders are the most cause of death in diabetics and above all stroke, whereas mortality due to neoplasms is higher in non-diabetic patients. Diabetes is an important risk factor of mortality in hemodialysis patients.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1492-7535.2004.0085w.x

Affiliations: Nephrology Unit, Lamentin Hospital, Martinique.

Publication date: January 1, 2004

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