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Changing patterns of bleeding in patients with severe haemophilia A

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Previous studies on the pattern of joint bleeding in patients with haemophilia have reported that the knee joint is most frequently affected. Home treatment data reporting bleeding frequency and location collected from 100 patients registered at six haemophilia centres in the UK have been analysed to determine current patterns of bleeding. Bleeding frequency has markedly decreased although bleeding into joints remains the main characteristic of haemophilia. However, the ankle joint has replaced the knee joint as the most common joint affected. Furthermore, it seems that the frequency of knee joint bleeding is also less than the elbow joint suggesting that the traditional pattern of joint bleeding in haemophilia has now changed significantly.

Keywords: ankle; bleeding pattern; haemarthrosis; haemophilia

Document Type: Research Article


Affiliations: 1: Kent Haemophilia Centre, Kent and Canterbury Hospital, Canterbury; 2: Department of Haematology, Glasgow Royal Infirmary, Glasgow; 3: Department of Haematology, University Hospital Wales, Cardiff; 4: Oxford Haemophilia Centre, Churchill Hospital, Oxford; 5: Department of Haematology, University Hospitals Nottingham, Queens Medical Campus, Nottingham; and 6: Haemophilia Centre, Addenbrookes Hospital, Cambridge University Hospitals, Cambridge, UK

Publication date: November 1, 2009

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