Skip to main content

Emerging clinical concerns in the ageing haemophilia patient

Buy Article:

$51.00 plus tax (Refund Policy)



The availability of safe replacement clotting factor concentrates together with effective antiviral drugs to treat human immunodeficiency and hepatitis C viruses and the provision of care at designated haemophilia treatment centres have resulted in a new phenomenon in haemophilia management – the ageing patient. Today, increasing numbers of persons with haemophilia (PWH) are middle-aged and older, and they face the same age-related health issues as the general population. The impact of these risks on PWH is unclear, however, and there is a paucity of information about how to manage comorbidities in this patient population. This review focuses on five comorbidities that uniquely affect older PWH: cardiovascular disease, liver disease, cancer, renal disease and joint disease. Available research is summarized and potential management approaches are suggested.

Keywords: ageing; comorbidities; haemophilia

Document Type: Research Article


Affiliations: 1: Penn Comprehensive Hemophilia Program, University of Pennsylvania School of Medicine, Philadelphia, PA, USA 2: Georgetown University Hospital, Lombardi Cancer Center, Washington, DC, USA 3: Mount Sinai School of Medicine, New York, NY, USA 4: DMC Karmanos Cancer Institute Comprehensive Center for Bleeding Disorders and Thrombosis, Detroit, MI, USA 5: University of California at San Francisco, San Francisco, CA, USA 6: Mary M. Gooley Hemophilia Center, Rochester, NY, USA 7: Orthopaedic Hospital of Los Angeles, Hemophilia Treatment Center, Los Angeles, CA, USA 8: University of Pittsburgh Medical Center and Hemophilia Center of Western Pennsylvania, Pittsburgh, PA, USA 9: Northwestern University, Division of Hematology/Oncology, Chicago, IL, USA 10: Baxter Healthcare, Westlake Village, CA, USA

Publication date: November 1, 2009

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Partial Open Access Content
Partial Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more