Clinical characteristics and blood product usage in AIDS-associated lymphoma in haemophiliacs: a case-control study

Authors: Ragni M.V.^{1, *}; Belle S.H.¹; Bass D.¹; Duerstein S.¹; Kingsley L.A.¹

Source: Haemophilia, Volume 4, Number 6, November 1998 , pp. 826-835(10)

Publisher: Wiley-Blackwell

Abstract:

In order to determine risk factors associated with the development of AIDS-associated lymphoma (AIDS-NHL) in individuals with haemophilia, we undertook a case-control study of 25 patients with AIDS-NHL identified prospectively in the multicentre Hemophilia Malignancy Study (HMS) and 100 haemophilia controls with AIDS matched 1:4 by age and date of AIDS diagnosis. Clinical, laboratory and lifestyle characteristics and blood product usage during the 2 years before seroconversion and AIDS or AIDS-NHL diagnosis were compared between cases and controls. AIDS-NHL cases had higher haemoglobin, platelets, %CD4 and white blood count, with the latter approaching significance, 5700 L^-1 vs. 4000 L^-1, P = 0.063. The proportion of cases receiving antiretroviral treatment prior to diagnosis was similar to that of AIDS-controls, 72% vs. 86%, but a significantly lower proportion of cases had been treated with intravenous pentamidine, 4% vs. 26%, P = 0.048. There were no differences between cases and controls in prevalence of antibody to hepatitis B or hepatitis C, HIV-related symptoms, lifestyle characteristics, or in the type or amount of blood product usage. Thus, clinical, lifestyle characteristics, antiviral drug treatment and blood product usage appear to have little, if any, effect on the development of AIDS lymphoma in HIV(+) patients with haemophilia.

Keywords: AIDS; blood products; case control; haemophilia; HIV; lymphoma

Language: English

Document Type: Research article

Affiliations: 1: Department of Medicine, Division of Hematology, University of Pittsburgh, School of Medicine, the Hemophilia Center of Western Pennsylvania, and the Department of Epidemiology, Graduate School of Public Health, Pittsburgh, PA, USA *

Publication date: 1998-11-01

• In this: publication
• By this: publisher
• In this Subject: Anatomy & Physiology ,  Internal Medicine
• By this author: Ragni M.V. ;  Belle S.H. ;  Bass D. ;  Duerstein S. ;  Kingsley L.A.

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