Senile cardiac amyloidosis

Authors: Ako, Junya; Sagawa, Kayo; Iijima, Katsuya; Ohike, Yumiko; Watanabe, Tokumitsu; Kozaki, Koichi; Yoshizumi, Masao; Ouchi, Yasuyoshi

Source: Geriatrics and Gerontology International, Volume 1, Numbers 1-2, December 2001 , pp. 65-68(4)

Publisher: Wiley-Blackwell

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Abstract:

A case of senile cardiac amyloidosis with recurrent episodes of congestive heart failure is reported here. An 83-year-old woman with a history of hypertension was admitted for the treatment of worsening dyspnea. The echocardiography revealed diffuse mild hypokinesis of the left ventricle with an ejection fraction of 46%. An elevated E wave and shortened deceleration time in the left ventricular inflow waveform was demonstrated with Doppler echocardiography, which suggested that the nature of the heart failure was restrictive. The patient required hospitalization for the treatment of congestive heart failure four times in 2 years. An autopsy revealed deposition of prealbumin-positive amyloid substance in the atrial myocardium and the intramyocardial arterioles of the left ventricle. Recurrent congestive heart failure was presumed to be a result of diastolic dysfunction due to senile cardiac amyloidosis.

Keywords: aged; amyloidosis; diastolic function

Document Type: Research article

DOI: http://dx.doi.org/10.1046/j.1444-1586.2001.00003.x

Affiliations: 1: Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

Publication date: 2001-12-01