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The effect of dietary vitamin K (phylloquinone and menadione) levels on the vertebral formation in mummichog Fundulus heteroclitus

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The effect of different dosages of vitamin K, either as phylloquinone or menadione sodium bisulfite (MSB), on vertebrae formation during growth of mummichog Fundulus heteroclitus was investigated. Diets without vitamin K caused a significantly higher incidence of bone deformity in fish than diets supplemented with MSB or phylloquinone (P < 0.01). These results indicate that vitamin K is essential for mummichog. A massive dose of MSB caused a high incidence of bone deformity compared with a lower dose, while an increased dose of phylloquinone brought about no significant difference in deformity incidence. The vertebral deformity was significantly higher (P < 0.01) in fish fed a vitamin K-free diet (Control Group) and MSB-supplemented diet (Group MSB25) compared to fish fed a phylloquinone-supplemented diet (Group PK1). These results indicate that phylloquinone is more suitable than MSB as a vitamin K source in fish feed.

Keywords: larvae; menadione sodium bisulfite; phylloquinone; vertebral formation

Document Type: Research Article

Affiliations: National Research Institute of Fisheries Science, Yokohama, Kanagawa 236-8648, Japan

Publication date: 2001-02-01

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