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Low frequency stimulation decreases seizure activity in a mutation model of epilepsy
Authors: Kile, Kara Buehrer; Tian, Nan; Durand, Dominique M.
Source: Epilepsia, Volume 51, Number 9, September 2010 , pp. 1745-1753(9)
Publisher: Wiley-Blackwell
Abstract:
Summary Purpose: To investigate brain electrical activity in Q54 mice that display spontaneous seizures because of a gain-of-function mutation of the Scn2a sodium channel gene, and to evaluate the efficacy of low frequency deep brain stimulation (DBS) for seizure frequency reduction. Methods: Electroencephalography (EEG), electromyography (EMG), and hippocampal deep electrodes were implanted into Q54 mice expressing an epileptic phenotype (n = 6). Chronic six channel recordings (wideband, 0.1-300 Hz) were stored 24 h a day for more than 12 days. Low frequency stimulation (LFS) (3 Hz, square wave, biphasic, 100 μs, 400 μA) was applied to the ventral hippocampal commissure (VHC) in alternating 5 min cycles (on or off) 24 h a day for a period of 4 days. Results: LFS (3 Hz) resulted in a significant reduction in seizure frequency and duration (21% and 35%, p < 0.05), when applied to the VHC of epileptic Q54 mice (n = 6). Seizure frequency was not directly affected by stimulation state (“on” vs. “off”). Conclusion: LFS applied at a frequency of 3 Hz significantly reduced seizure frequency and duration in the Q54 model. Furthermore, the reduction of seizure frequency and duration by LFS was not immediate but had a delayed and lasting effect, supporting complex, indirect mechanisms of action.Keywords: Epilepsy; DBS; LFS; Sodium Channel; Scn2a
Document Type: Research article
DOI: http://dx.doi.org/10.1111/j.1528-1167.2010.02679.x
Publication date: 2010-09-01
- In this: publication
- By this: publisher
- In this Subject: Neurology & Psychiatry
- By this author: Kile, Kara Buehrer ; Tian, Nan ; Durand, Dominique M.
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