@article {Libbey:June 2008:0013-9580:1066,
author = "Libbey, Jane E.",
author = "Kirkman, Nikki J.",
author = "Smith, Matthew C.P.",
author = "Tanaka, Tomoko",
author = "Wilcox, Karen S.",
author = "White, H. Steve",
author = "Fujinami, Robert S.",
title = "Seizures following picornavirus infection",
journal = "Epilepsia",
volume = "49",
year = "June 2008",
abstract = "Summary Purpose: We demonstrate the establishment and characterization of a novel virus infection-induced seizure model in C57BL/6 mice. Methods: C57BL/6 mice were infected with Theiler's murine encephalomyelitis virus (TMEV) or mock infected. Mice were followed for seizures, weight change, body temperature, motor function (righting reflex, rotorod) and neurological manifestations (inflammation [perivascular cuffing], pyknotic neurons, transforming growth factor [TGF]-β expression). Results: C57BL/6 mice are susceptible to seizures induced by TMEV infection. Approximately 50% of C57BL/6 mice develop transient afebrile seizures. Motor function and coordination are impaired in seized mice. Pyramidal neuron pyknosis and TGF-β expression correlate with seizure activity in the hippocampus. Discussion: The characterization of this model will enable the investigation of viral and immune contributions in the central nervous system to the development of seizure disorders in humans.",
pages = "1066-1074(9)",
url = "http://www.ingentaconnect.com/content/bsc/epi/2008/00000049/00000006/art00015"
doi = "doi:10.1111/j.1528-1167.2008.01535.x"
}