@article {Wang-Tilz:February 2006:0013-9580:227, author = "Wang-Tilz, Ying", author = "Tilz, Christian", author = "Wang, Bing", author = "Tilz, Gernot P.", author = "Stefan, Hermann", author = "Bercovici, Eduard", author = "Cortez, Miguel A.", author = "Wang, Xiaomei", author = "Snead, O. Carter", author = "Debanne, Dominique", author = "Thompson, Scott M.", author = "Gahwiler, Beat H.", author = "Patrylo, Peter R.", author = "Browning, Ronald A.", author = "Cranick, Scott", author = "Musto, Alberto", author = "Bazan, Nicolas G.", author = "Tsai, Min-Lan", author = "Leung, L. Stan", author = "Gorji, Ali", author = "Stemmer, Nina", author = "Rambeck, Bernhard", author = "Jurgens, Uwe", author = "May, Theodor", author = "Pannek, Heinz Wolfgang", author = "Behne, Friedrich", author = "Ebner, Alois", author = "Straub, Hiedrun", author = "Speckmann, Erwin-Josef", title = "Basic Science", journal = "Epilepsia", volume = "47", year = "February 2006", abstract = "Influence of Lamotrigine and Topiramate on MDR1 Expression in Difficult-to-Treat Temporal Lobe Epilepsy

<namegroup type="author"> <name type="author"> <forenames>Ying</forenames> <surname>Wang-Tilz</surname> </name>, <name type="author"> <forenames>Christian</forenames> <surname>Tilz</surname> </name>, <name type="author"> <forenames>Bing</forenames> <surname>Wang</surname> </name>, <name type="author"> <forenames>Gernot P.</forenames> <surname>Tilz</surname> </name>, and <name type="author"> <forenames>Hermann</forenames> <surname>Stefan</surname> </name> </namegroup> Some individuals with epilepsy appear resistant to most or all antiepileptic medications. One possible explanation for this resistance is the presence of a gene called MDR1 that causes production in the brain of a substance called p-glycoprotein (P-gp). We studied a model of epilepsy in rats produced by repeated injections of Coriaria lactone, an epileptogenic plant toxin. The clinical antiepileptic drugs, topiramate and lamotrigine, significantly reduced seizures. With these two drugs, P-gp was not increased in brain. In contrast, carbamazepine and valproate did increase brain P-gp, and these drugs were less beneficial against the seizures. These results suggest that attention could usefully be paid to whether medications activate multiple drug-resistance genes in brain, because such an effect could counteract the effectiveness of a medication. Epilepsia 2006;47(2).", pages = "227-228(2)", url = "http://www.ingentaconnect.com/content/bsc/epi/2006/00000047/00000002/art00001" doi = "doi:10.1111/j.1528-1167.2006.00413_1.x" }