Basic Science

Authors: Wang-Tilz, Ying; Tilz, Christian; Wang, Bing; Tilz, Gernot P.; Stefan, Hermann; Bercovici, Eduard; Cortez, Miguel A.; Wang, Xiaomei; Snead, O. Carter; Debanne, Dominique; Thompson, Scott M.; Gähwiler, Beat H.; Patrylo, Peter R.; Browning, Ronald A.; Cranick, Scott; Musto, Alberto; Bazan, Nicolas G.; Tsai, Min-Lan; Leung, L. Stan; Gorji, Ali; Stemmer, Nina; Rambeck, Bernhard; Jürgens, Uwe; May, Theodor; Pannek, Heinz Wolfgang; Behne, Friedrich; Ebner, Alois; Straub, Hiedrun; Speckmann, Erwin-Josef

Source: Epilepsia, Volume 47, Number 2, February 2006 , pp. 227-228(2)

Publisher: Wiley-Blackwell

Abstract:

Influence of Lamotrigine and Topiramate on MDR1 Expression in Difficult-to-Treat Temporal Lobe Epilepsy

<namegroup type="author"> <name type="author"> <forenames>Ying</forenames> <surname>Wang-Tilz</surname> </name>, <name type="author"> <forenames>Christian</forenames> <surname>Tilz</surname> </name>, <name type="author"> <forenames>Bing</forenames> <surname>Wang</surname> </name>, <name type="author"> <forenames>Gernot P.</forenames> <surname>Tilz</surname> </name>, and <name type="author"> <forenames>Hermann</forenames> <surname>Stefan</surname> </name> </namegroup> Some individuals with epilepsy appear resistant to most or all antiepileptic medications. One possible explanation for this resistance is the presence of a gene called MDR1 that causes production in the brain of a substance called p-glycoprotein (P-gp). We studied a model of epilepsy in rats produced by repeated injections of Coriaria lactone, an epileptogenic plant toxin. The clinical antiepileptic drugs, topiramate and lamotrigine, significantly reduced seizures. With these two drugs, P-gp was not increased in brain. In contrast, carbamazepine and valproate did increase brain P-gp, and these drugs were less beneficial against the seizures. These results suggest that attention could usefully be paid to whether medications activate multiple drug-resistance genes in brain, because such an effect could counteract the effectiveness of a medication. Epilepsia 2006;47(2).

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1528-1167.2006.00413_1.x

Publication date: 2006-02-01

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• In this Subject: Neurology & Psychiatry
• By this author: Wang-Tilz, Ying ;  Tilz, Christian ;  Wang, Bing ;  Tilz, Gernot P. ;  Stefan, Hermann ;  Bercovici, Eduard ;  Cortez, Miguel A. ;  Wang, Xiaomei ;  Snead, O. Carter ;  Debanne, Dominique ;  Thompson, Scott M. ;  Gähwiler, Beat H. ;  Patrylo, Peter R. ;  Browning, Ronald A. ;  Cranick, Scott ;  Musto, Alberto ;  Bazan, Nicolas G. ;  Tsai, Min-Lan ;  Leung, L. Stan ;  Gorji, Ali ;  Stemmer, Nina ;  Rambeck, Bernhard ;  Jürgens, Uwe ;  May, Theodor ;  Pannek, Heinz Wolfgang ;  Behne, Friedrich ;  Ebner, Alois ;  Straub, Hiedrun ;  Speckmann, Erwin-Josef

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