No support for a truncated interferon-α17 allele as risk factor for MS

Authors: Nyström, M.¹; Ruuth, K.²; Lundgren, E.²; Sundström, P.¹

Source: European Journal of Neurology, Volume 14, Number 11, November 2007 , pp. 1302-1304(3)

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Abstract:

Cytokines have a central role in multiple sclerosis (MS) pathogenesis and may contribute to the aetiology of MS. A polymorphism in the IFNA17 gene with an allele carrying a pre-mature stop codon has been suggested to convey a 26-fold increased risk for MS. We investigated the possible association between this polymorphism and MS using population-based samples from a genetically well-characterized population. The IFNA17 gene variant was found in 2.8% of 327 MS cases and 3.3% of 698 referents (P = 0.64). Thus, our study does not support an association between the IFNA17 allele and risk for MS.

Keywords: candidate gene; interferon-α; multiple sclerosis; polymorphism

Document Type: Short communication

DOI: http://dx.doi.org/10.1111/j.1468-1331.2007.01953.x

Affiliations: 1: Department of Clinical Neuroscience, Umeå University, Umeå, Sweden; 2: Department of Molecular Biology, Umeå University, Umeå, Sweden

Publication date: 2007-11-01