@article {Fidani:July 2007:1351-5101:745,
	author = "Fidani, L.",
	author = "Clarimon, J.",
	author = "Goulas, A.",
	author = "Hatzitolios, A. I.",
	author = "Evans, W.",
	author = "Tsirogianni, E.",
	author = "Hardy, J.",
	author = "Kotsis, A.",
	title = "Association of phosphodiesterase 4D gene G0 haplotype and ischaemic stroke in a Greek population",
	journal = "European Journal of Neurology",
	volume = "14",
	year = "July 2007",
	abstract = "We have examined the association of phosphodiesterase 4D (<I>PDE4D</I>) single nucleotide polymorphism (SNP45) and microsatellite marker AC008818-1 with ischaemic stroke, in an independent cohort of Greek patients and control individuals with no clinical manifestations of vascular disease. Significantly different distributions were observed with respect to the AC008818-1 alleles, with allele 148 associating with an increased risk of stroke incidence, and allele 144 with a protective effect. In addition, the haplotype defined by allele 148 and G allele of SNP45 was found to be significantly increased in patients even though no statistically significant differences emerged with respect to SNP45 alone. The previously established association of a <I>PDE4D</I> gene haplotype with ischaemic stroke in a population from Iceland was independently confirmed in our Greek population, suggesting that PDE4D may be involved in the aetiology and pathogenesis of stroke.",
	pages = "745-749(5)",
	url = "http://www.ingentaconnect.com/content/bsc/ene/2007/00000014/00000007/art00029"
	doi = "doi:10.1111/j.1468-1331.2007.01767.x"
}