IngentaConnect Association of phosphodiesterase 4D gene G0 haplotype and ischaem...

Authors: Fidani, L.¹; Clarimon, J.²; Goulas, A.³; Hatzitolios, A. I.⁴; Evans, W.²; Tsirogianni, E.⁴; Hardy, J.; Kotsis, A.¹

Source: European Journal of Neurology, Volume 14, Number 7, July 2007 , pp. 745-749(5)

Publisher: Blackwell Publishing

Abstract:

We have examined the association of phosphodiesterase 4D (PDE4D) single nucleotide polymorphism (SNP45) and microsatellite marker AC008818-1 with ischaemic stroke, in an independent cohort of Greek patients and control individuals with no clinical manifestations of vascular disease. Significantly different distributions were observed with respect to the AC008818-1 alleles, with allele 148 associating with an increased risk of stroke incidence, and allele 144 with a protective effect. In addition, the haplotype defined by allele 148 and G allele of SNP45 was found to be significantly increased in patients even though no statistically significant differences emerged with respect to SNP45 alone. The previously established association of a PDE4D gene haplotype with ischaemic stroke in a population from Iceland was independently confirmed in our Greek population, suggesting that PDE4D may be involved in the aetiology and pathogenesis of stroke.

Keywords: genetics; gene polymorphism; ischaemic stroke; phosphodiesterase 4D

Document Type: Research article

DOI: 10.1111/j.1468-1331.2007.01767.x

Affiliations: 1: Department of General Biology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece 2: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA 3: Department of Experimental Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece 4: First Propedeutic Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Association of phosphodiesterase 4D gene G0 haplotype and ischaemic stroke in a Greek population