A polymorphism of the aldehyde dehydrogenase 2 gene is a risk factor for multiple lacunar infarcts in Japanese men: the Takahata Study

Authors: Nagasawa, H.¹; Wada, M.¹; Arawaka, S.¹; Kawanami, T.¹; Kurita, K.¹; Daimon, M.¹; Adachi, M.²; Hosoya, T.²; Emi, M.³; Muramatsu, M.; Kato, T.¹

Source: European Journal of Neurology, Volume 14, Number 4, April 2007 , pp. 428-434(7)

Publisher: Wiley-Blackwell

Abstract:

The objective of the present study was to examine the association between a polymorphism of the aldehyde dehydrogenase 2 (ALDH2) gene and lacunar infarcts of the brain. We conducted a population-based, cross-sectional study on residents from two age groups (61- and 72-year olds). A total of 376 subjects participated in the study, which included brain magnetic resonance image and genetic analysis of the ALDH2 gene. Of the 61- and 72-year-old subjects, 46.4% and 64.3%, respectively, had one or more lacunar infarcts. The average number of infarcts also increased from 2.0 to 2.8 in men and from 2.3 to 3.5 in women. No significant association between the ALDH2 genotype and the presence of lacunar infarction (≥1) was found. However, in subjects with lacunar infarction, the genotype of ALDH2 *1/*1 was associated with a larger number of the lesion [`single' versus `multiple' odds ratio (OR) 3.73, 95%CI: 1.43-9.74] in men. The OR was comparable even after adjusting for alcohol consumption, tobacco habits, age, hypertension, hypercholesterolemia, and diabetes mellitus (DM) (OR 3.88; 95% CI: 1.10-13.66). In women, there was no significant association between the ALDH2 genotypes and lacunar infarcts. The present study revealed that the ALDH2 *1/*1 genotype was significantly associated with the prevalence of multiple lacunar infarcts in Japanese men.

Keywords: aldehyde dehydrogenase 2; brain magnetic resonance image; lacunar infarct; polymorphism; population-based study

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1468-1331.2007.01700.x

Affiliations: 1: Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata; 2: Department of Radiology, Yamagata University School of Medicine, Yamagata; 3: Hubit Genomics, Inc., Tokyo; and

Publication date: 2007-04-01

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• In this Subject: Neurology & Psychiatry ,  Public Health
• By this author: Nagasawa, H. ;  Wada, M. ;  Arawaka, S. ;  Kawanami, T. ;  Kurita, K. ;  Daimon, M. ;  Adachi, M. ;  Hosoya, T. ;  Emi, M. ;  Muramatsu, M. ;  Kato, T.

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